Quinolinic acid quin is an endogenous n methyl d aspartate receptor agonist synthesized from l tryptophan via the kynurenine pathway and thereby has the potential of mediating n methyl d aspartate neuronal damage and dysfunction conversely the related metabolite kynurenic acid is an antagonist of n methyl d aspartate receptors and could . In the late 1970s and early 1980s it became clear that intraventricular administration of several kynurenines could cause convulsions and that one of the kynurenines quinolinic acid was an agonist of a sub population of nmda receptors and caused excitotoxic neuronal death. 1 biosynthesis of quinolinic acid quin tryptophan trp is an essential amino acid that has various important biological functions in mammals about 90 of dietary trp is metabolized along the kynurenine pathway kp figure 1 1 2 which represents the major catabolic route of trp and a source of nicotinamide adenine nucleotide nad a cofactor in cellular respiration and energy . Lc ms ms based quantification of kynurenine metabolites tryptophan monoamines and neopterin in plasma cerebrospinal fluid and brain we established an lc ms ms method to measure 11 molecules namely tryptophan kyn 3 oh kyn 3 oh anthranilic acid quinolinic acid picolinic acid kynurenic acid kynurenines in the mammalian
How it works:
1. Register Trial Account.
2. Download The Books as you like ( Personal use )